autologous stem cell transplant procedure

AUTOLOGOUS STEM CELL TRANSPLANT PROCEDURE FULL

AUTOLOGOUS STEM CELL TRANSPLANT PROCEDURE FULL

The full recovery of the immune system can take much longer. But because stem cell transplants destroy and rebuild the immune system, patients are left immunocompromised and more vulnerable to infection fr common germs and fungi. The process of growing new blood cells after receiving a transplant generally takes between two and four weeks. Which type of transplant is appropriate for a patient is determined by his or her transplant physician. These types of transplants are also used to treat blood disorders and immune system diseases, such as aplastic anemia, sickle cell anemia, myelodysplastic syndromes, Waldenström’s macroglobulinemia, and myeloproliferative disorders. Stem Cell Transplants Rise Among Older Patients.What is a Reduced Intensity Stem Cell Transplant?.What is Haploidentical Stem Cell Transplantation?.This is called the graft-versus-tumor effect. The intensity of the therapy is insufficient to eradicate the malignancy, so this form of transplantation depends on the immunologic recognition of the cancer by the immune system of the donor. In a reduced-intensity allogeneic transplant, doctors suppress the recipient’s immune system enough so the donor stem cells can take root, or “engraft,” there. In a myeloablative transplant, large doses of chemotherapy – or a combination of chemotherapy and radiation – are used to overcome resistance and eradicate a patient’s malignancy. There are two types of allogeneic transplants. The stem cell donor may be related to the patient, or they may be an unrelated volunteer found through a donor registry search such as the National Marrow Donor Program. Following conditioning treatment, the patient’s stem cells are returned to the body to help it produce healthy red and white blood cells and platelets.Īn allogeneic transplant uses stem cells from a donor whose human leukocyte antigens (HLA) are acceptable matches to the patient’s. Stem cells are intrinsically normal, and they are collected to allow blood cell recovery after the administration of high dose therapy that would otherwise irreversibly damage them. In this procedure, stem cells are collected from the patient and frozen in liquid nitrogen before transplant conditioning. Autologous versus allogenic transplantĪn autologous transplant uses a person’s own stem cells. Both kinds of stem cell transplantations are a common treatment option for cancers such as leukemia, lymphoma, and multiple myeloma.

Two of the most common types of stem cell transplants are autologous and allogeneic transplants. It is often lifesaving for patients with blood cancer and serious blood disorders.Ī person may need a transplant for a few different reasons: when their body cannot make the blood cells that it needs, because their bone marrow or blood cells have become diseased and need to be replaced, or because they have a disease that is treated with high doses of chemotherapy and/or radiation, which destroys cancerous and stem cells at the same time. An allogeneic transplant uses stem cells from a donor whose human leukocyte antigens (HLA) are acceptable matches to the patient’s.Ī stem cell transplant is a procedure during which doctors either replace diseased or ineffective stem cells with healthy new stem cells or allow high-dose treatment for lymphoma, some testicular cancers, and other diseases.An autologous transplant uses a person’s own stem cells.

Autologous stem cell transplant procedure